Sandbox: DDx Kidney mass

• 60-70 male patients
• Haematuria
• Flank pain
• Palpable flank mass
• von Hippel-Lindau syndrome

• Polygonal cells, clear cytoplasm, and a central nucleus
• Delicate branching vasculature
• "Chicken wire-like" vasculature
• Hyaline bodies common

• Chromosome 3 mutation
• VHL gene mutation
• Gain of chromosome 5

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying