Sandbox: DDx Kidney mass

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  • 50-60 yo male
  • Asymptomatic
  • Incidental finding on imaging
  • May have hematuria and flank pain
  • Palpable flank mass
  • Cells arranged in nests
  • Granular eosinophilic cytoplasm
  • Nuclei uniform and round with no pleomorphism


  • Large well demarcated tumors
  • Large hetrogenous mass
  • Perinephric fat-stranding
  • Calcification

Nonmalignant causes

anaplastic sarcoma clear cell sarcoma mesoblastic nephroma metanephric stromal tumor nephroblastomatosis / nephrogenic rests neuroblastoma oncocytoid carcinoma after neuroblastoma ossifying