Metanephric adenoma overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]
Overview
Metanephric adenoma (MA)is a rare, benign tumor of the kidney.
Historical Perspective
Metanephric adenoma was first described by Brisigotti, Cozzutto et al. in 1992.[1]
Classification
There is no classification system established for metanephric adenoma.
Pathophysiology
On gross pathology, a sharply circumscribed, nonencapsulated solitary mass is the characteristic finding of metanephric adenoma. On microscopic histopathological analysis, small uniform cells with fine chromatin and smooth nuclear membrane, variable architecture, and psammoma bodies are characteristic findings of metanephric adenoma.
Causes
Metanephric adenoma may be caused by the allelic changes of tumor suppressor gene on chromosome 2p13. [2]
References
- ↑ Brisigotti M, Cozzutto C, Fabbretti G, Sergi C, Callea F (1992). "Metanephric adenoma". Histology and Histopathology. 7 (4): 689–92. PMID 1333853.
- ↑ Pesti T, Sükösd F, Jones EC, Kovacs G (2001). "Mapping a tumor suppressor gene to chromosome 2p13 in metanephric adenoma by microsatellite allelotyping". Human Pathology. 32 (1): 101–4. doi:10.1053/hupa.2001.21132. PMID 11172302.