Intracerebral metastases pathophysiology
|
Intracerebral metastases Microchapters |
|
Differentiating Intracerebral Metastases from other Diseases |
|---|
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Intracerebral metastases pathophysiology On the Web |
|
American Roentgen Ray Society Images of Intracerebral metastases pathophysiology |
|
Risk calculators and risk factors for Intracerebral metastases pathophysiology |
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing.
Overview
Pathophysiology
Pathogenesis
Gross Pathology
- Typically metastases are sharply demarcated from the surrounding parenchyme and usually there is a zone of peritumoral edema out of proportion with the tumor size.
- Common intracranial sites associated with subependymal giant cell astrocytoma include:[1]
- Cerebrum (80%)
- Cerebellum (15%)
- Brain stem (5% )
Gallery
-
![This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]](/images/1/12/THYROID_PAPILLARY_CARCINOMA_METASTATIC_TO_BRAIN.jpg)
This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]
![This solitary brain metastasis from thyroid papillary carcinoma resulted in neurological symptoms. The thyroid primary was clinically occult. (Courtesy of Dr. Nikola Kostich, Minneapolis, MN.).[2]](/index.php/File:THYROID_PAPILLARY_CARCINOMA_METASTATIC_TO_BRAIN.jpg)
Microscopic Pathology
The histopathological appearance of intracerebral metastases may vary with the type of primary tumor. Common findings are listed below:[3][4]
- Tubule formation/glands
- Well-circumscribed and sharply demarcated from surrounding tissue (with the exception of melanoma metastasis)
- Mitoses
- Nuclear atypia
- Nuclear hyperchromasia
- Variation of nuclear size
- Variation of nuclear shape
Gallery
-
![Very low magnification micrograph demonstrating metastatic adenocarcinoma that from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and Purkinje cell loss.[5]](/images/a/ae/Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg)
Very low magnification micrograph demonstrating metastatic adenocarcinoma that from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and Purkinje cell loss.[5]
-
![High magnification micrograph demonstrating metastatic adenocarcinoma that is from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum has Bergmann gliosis and Purkinje cell loss.[5]](/images/0/06/Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg)
High magnification micrograph demonstrating metastatic adenocarcinoma that is from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum has Bergmann gliosis and Purkinje cell loss.[5]
-
![High magnification micrograph of a brain metastasis on HPS stain demonstrating normal brain tissue on the left and tumor cells on the right. The sharp demarcation between tumor and normal is typical of brain metastases.[5]](/images/9/9f/Brain_metastasis_-_high_mag.jpg)
High magnification micrograph of a brain metastasis on HPS stain demonstrating normal brain tissue on the left and tumor cells on the right. The sharp demarcation between tumor and normal is typical of brain metastases.[5]
-
![Adenocarcinoma infiltrating the brain in a case of lung cancer on H&E stain.[5]](/images/a/a4/Brain_metastasis_-_high_mag_2.jpg)
Adenocarcinoma infiltrating the brain in a case of lung cancer on H&E stain.[5]
![Very low magnification micrograph demonstrating metastatic adenocarcinoma that from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum seen on the image has Bergmann gliosis and Purkinje cell loss.[5]](/index.php/File:Metastatic_adenocarcinoma_-_cerebellum_-_very_low_mag.jpg)
![High magnification micrograph demonstrating metastatic adenocarcinoma that is from a colorectal primary, i.e. colorectal carcinoma, by immunostains on HPS stain. The cerebellum has Bergmann gliosis and Purkinje cell loss.[5]](/index.php/File:Metastatic_adenocarcinoma_-_cerebellum_-_high_mag.jpg)
![High magnification micrograph of a brain metastasis on HPS stain demonstrating normal brain tissue on the left and tumor cells on the right. The sharp demarcation between tumor and normal is typical of brain metastases.[5]](/index.php/File:Brain_metastasis_-_high_mag.jpg)
![Adenocarcinoma infiltrating the brain in a case of lung cancer on H&E stain.[5]](/index.php/File:Brain_metastasis_-_high_mag_2.jpg)
References
- ↑ Khuntia, Deepak (2015). "Contemporary Review of the Management of Brain Metastasis with Radiation". Advances in Neuroscience. 2015: 1–13. doi:10.1155/2015/372856. ISSN 2356-6787.
- ↑ Gross image of brain metastases. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015
- ↑ Microscopic features of brain metastasis. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015
- ↑ Microscopic appearance of brain metastases. Dr Bruno Di Muzio and Dr Trent Orton et al. Radiopaedia 2015. http://radiopaedia.org/articles/brain-metastases. Accessed on November 10, 2015
- ↑ 5.0 5.1 5.2 5.3 Microscopic images of brain metastasis. Libre pathology 2015. http://librepathology.org/wiki/index.php/Brain_metastasis. Accessed on November 10, 2015