Waldenström's macroglobulinemia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Common causes of waldenström's macroglobulinemia include genetic such as somatic mutation in MYD88 and CXCR4, environmental such as exposure to farming, pesticides, wood dust, and organic solvents, and autoimmune factors such as chronic immune stimulationand autoimmune disorders.[1][2]
Causes
- The most common causes of waldenström's macroglobulinemia is somatic mutation in MYD88 (90% of patients) and CXCR4 (27% of patients).[1]
- Less common causes of waldenström's macroglobulinemia include:
- Chromosomal abnormalities: deletions of 6q23 and 13q14, and gains of 3q13-q28, 6p and 18q
- Environmental factors including exposure to farming, pesticides, wood dust, and organic solvents
- Chronic immune stimulation and autoimmune disorders[2]
References
- ↑ 1.0 1.1 Waldenström's macroglobulinemia. Wikipedia (2015). https://en.wikipedia.org/wiki/Waldenström%27s_macroglobulinemia#cite_note-19 Accessed on November 6, 2015
- ↑ 2.0 2.1 Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM (2011). "Oncogenically active MYD88 mutations in human lymphoma". Nature. 470 (7332): 115–9. doi:10.1038/nature09671. PMID 21179087.