Medullary thyroid cancer laboratory findings

Medullary thyroid cancer Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Medullary thyroid cancer from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
CT
Echocardiography or Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Medullary thyroid cancer laboratory findings On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Medullary thyroid cancer laboratory findings All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Medullary thyroid cancer laboratory findings
CDC on Medullary thyroid cancer laboratory findings
Medullary thyroid cancer laboratory findings in the news
Blogs on Medullary thyroid cancer laboratory findings
Directions to Hospitals Treating Medullary thyroid cancer
Risk calculators and risk factors for Medullary thyroid cancer laboratory findings

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Overview

Laboratory findings consistent with the diagnosis of medullary thyroid cancer include decreased thyroid stimulating hormone, elevated calcitonin, and decreased calcium.

Laboratory Findings

• Blood or imaging tests may be done prior to or in lieu of a biopsy. The following blood tests are conducted:

• Thyroid stimulating hormone (TSH)
• thyroxine (T4)
• Triiodothyronine (T3)
• Calcitonin- Calcitonin is required for the diagnosis and follow up of medullary thyroid cancer. It is an important tumor marker.
• Carcinoembryonic antigen

• Tests for serum thyroid autoantibodies are sometimes done to rule out autoimmune thyroid disease.
• Laboratory findings consistent with the diagnosis of multiple endocrine neoplasia type 2 are tabulated below.

Laboratory findings

Test	Findings
Metabolic	Decreased thyroid stimulating hormone Antithyroid antibodies Elevated calcitonin Decreased calcium
Adapted from Arzu Tatlıpınar1 and İlkay Kartal [Updated 2015].The Evaluation of Thyroid Nodules. Journal of Thyroid Disorders & Therapy.2015.

Laboratory tests Normal Range Abnormal value Serum Thyroid stimulating hormone 0.4 - 4.0 milli-international units per liter <0.4 or >4.0 Antithyroid antibodies <35 IU/mL >35 IU/mL Serum calcitonin less than 10pg/mL >=100 pg/mL Serum calcium 8.9-10.1 mg/dL > 10.1 mg/dL or < 8.9 mg/dL References