Sandbox: Bone DDx
- 50-70 yo males
- Deep, achy, dull pain
- Night time bone pain
- Limited range of joints motion
- Pathologic fracture
- Palpable lump or local mass effect
- Large calcified lesions
- Thin and expanded bone
- Multiple surface erosions
- Cortical thickening
- Lytic intralesional calcification
- Endosteal scalloping
- Moth eaten appearance
- Cortical remodelling, thickening and periosteal reaction
Bi-nucleation.
Hypochromatic enlarged nuclei.
Infiltration of lamellar bone ("invasion")
Increased cellularity