Pineal choriocarcinoma
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Synonyms and keywords: Pineal embryonal cell carcinoma; Pineal gland tumor; Brain tumor
Overview
- Pineal choriocarcinoma is a relatively rare malignant neoplasm and accounts for a small proportion of all intracranial germ cell tumors. It is an aggressive tumor and has a propensity to metastasise systemically. Pure pineal choriocarcinoma tumors secrete β-HCG.[1]
- On microscopic histopathological analysis, pineal choriocarcinoma is characterized by presence of intimately related syncytiotrophoblasts and cytotrophoblasts without formation of definite placental type villi. Syncytiotrophoblasts are large multi-nucleated cells with eosinophilic cytoplasm. They often surround the cytotrophoblasts, reminiscent of their normal anatomical relationship in chorionic villi. Cytotrophoblasts are polyhedral, mononuclear cells with hyperchromatic nuclei and a clear or pale cytoplasm.[2]
- Pineal choriocarcinoma accounts for 5% of all pineal masses and 10% of all intracranial germ cells tumors.[1]
- The peak age at diagnosis for pineal choriocarcinoma is 20-30 years.
- Common complications of pineal choriocarcinoma include:[3][4]
- CSF metastasis
- Ventricular hemorrhage
- Coma
- Systemic metastasis
References
- ↑ 1.0 1.1 Intracranial choriocarcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-choriocarcinoma. Accessed on December 7, 2015
- ↑ Pathology of choriocarcinoma. Wikipedia 2015. https://en.wikipedia.org/wiki/Choriocarcinoma. Accessed on December 7, 2015
- ↑ Kida Y, Banno M, Kanzaki M, Kobayashi T, Kageyama N (1985). "[Pineal choriocarcinoma presenting massive ventricular hemorrhage--a case report]". No Shinkei Geka. 13 (6): 641–5. PMID 3840234.
- ↑ Radiographic features of intracranial choriocarcinoma. Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/intracranial-choriocarcinoma. Accessed on December 7, 2015