Adenocarcinoma of the lung causes

Adenocarcinoma of the Lung Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Adenocarcinoma of the lung may caused by genetic mutations, including EGFR (7p11), KRAS (12p12), BRAF (7q34), and PIK3CA (3q26).

Causes

Genetic mutations

• Genes involved in the pathogenesis of adenocarcinoma of the lung include:

• EGFR (7p11)
• KRAS (12p12)
• BRAF (7q34)
• PIK3CA (3q26)
• ERBB2 (17q12)
• Translocation EML4/ALK
• Tyrosine kinase fusions

• ALK (2p23), ROS1 (6q22), and RET (10q11)

References

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