Chondroma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Chondromas arise from rests of growth plate cartilage or chondrocytes that are normally involved in the production and maintainence of the cartilaginous matrix, which consists mainly of collagen and proteoglycans.[1][2] On microscopic histopathological analysis, avascular lobules of hyaline cartilagenous matrix interspersed with chondrocytes, separated by normal marrow are characteristic findings of chondromas.[3] On gross pathology, small (usually less than 3 cm), translucent, grey blue, nodular lesions are characteristic findings of enchondroma.[4]
Pathophysiology
- Chondromas arise from rests of growth plate cartilage or chondrocytes that are normally involved in the production and maintainence of the cartilaginous matrix, which consists mainly of collagen and proteoglycans.[5][6]
- On microscopic histopathological analysis, avascular lobules of hyaline cartilagenous matrix interspersed with chondrocytes, separated by normal marrow are characteristic findings of chondromas.[3]
enchondroma is a chondroid tumor with slow growth pattern and mild biologic course; therefore, it must have a regular lobulation structure. Fibrous capsule of enchondroma is almost inactive with little blood vessels and low cellularity.
- On gross pathology, small (usually less than 3 cm), translucent, grey blue, nodular lesions are characteristic findings of enchondroma.[7]
Juxta-cortical chondromas (also known as periosteal chondromas) are rare benign chondral tumours that arise from the periosteum of tubular bones.[8]
Pathophysiology
Enchondromas arise from rests of growth plate cartilage/chondrocytes that subsequently proliferate and slowly enlarge and are composed of mature hyaline cartilage. Hence, they are seen in any bone formed from cartilage.
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References
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Chondrocytes. Wikipedia. https://en.wikipedia.org/wiki/Chondrocyte. Accessed on December 16, 2015.
- ↑ 3.0 3.1 Semenova LA, Bulycheva IV (2007). "[Chondromas (enchondroma, periosteal chondroma, enchondromatosis)]". Arkh Patol. 69 (5): 45–8. PMID 18074822.
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Chondrocytes. Wikipedia. https://en.wikipedia.org/wiki/Chondrocyte. Accessed on December 16, 2015.
- ↑ Enchondroma. Radiopedia. http://radiopaedia.org/articles/enchondroma Accessed on December 15, 2015
- ↑ Juxta-cortical chondroma. Radiopedia. http://radiopaedia.org/articles/juxta-cortical-chondroma Accessed on December 15, 2015