Paracoccidioidomycosis natural history, complications and prognosis
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Overview
Natural History
- The symptoms of acute/subacute PMC is usually develop in children and young adults, under 35 years. Start with inespecific symptoms such as:
- superficial node enlargement
- deep lymph node enlargement
- The symptoms of PMC chronic usually develop in the third decade of life, eventhough the infection can be acquired in the first decade of life [1].... Start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
Infection
- The infection can be adquired in the first decade of life. PMC infection has no manifested symptoms. [2]
Acute/subacute
Chronic
Complications
Complications that can develop as a result of PMC are:
- "Worsening of chronic obstructive pulmonary disease (COPD)
- Adrenal gland dysfunction (15-50%)
- dysphonia or laryngeal obstruction, or a combination of the two
- reduced mouth opening
- epilepsy or hydrocephalur, or both (6-25%)" [1]