Paracoccidioidomycosis natural history, complications and prognosis
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Overview
Natural History
- The symptoms of acute/subacute PMC is usually develop in children and young adults, under 35 years. Start with inespecific symptoms such as:
- superficial node enlargement
- deep lymph node enlargement
- The symptoms of PMC chronic usually develop in the third decade of life, eventhough the infection can be acquired in the first decade of life [1].... Start with symptoms such as ___. The symptoms of (disease name) typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
Infection
- The infection can be adquired in the first decade of life. PMC infection has no manifested symptoms. [2]
Acute/subacute
Chronic
Complications
Paracoccidioidomycosis develops sequelae frequently:
- Chronic obstructive pulmonary disease (COPD)
- Pulmonary fibrosis
- Adrenal gland insufficiency
- Superior airway obstruccion (dysphonia and laryngeal lesions)
- Difficulty for mouth opening
- Seizures
- Motor deficiency [3] [4]
Prognosis
References
- ↑ Vargas J, Vargas R. Paracoccidiodomicosis. Rev. enferm. infecc. trop.2009(1):49-56
- ↑ Fortes MR, Miot HA, Kurokawa CS, Marques ME, Marques SA (2011). "Immunology of paracoccidioidomycosis". An Bras Dermatol. 86 (3): 516–24. PMID 21738969.
- ↑ Wanke B, Aidê M. Chapter 6 - Paracoccidioidomycosis. J. bras. pneumol. 2009; 35(12):1245-1249
- ↑ Francesconi F, da Silva MT, Costa RL, et al. Long-term outcome of neuroparacoccidioidomycosis treatment. Rev Soc Bras Med Trop. 2011;44(1):22-25