Linitis plastica natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach that may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.[1][2] Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary. The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica. Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.[2]
Natural History
- Diffuse gastric adenocarcinoma or linitis plastica remains asymptomatic for a long time before diagnosis. Therefore, when a patient presents with symptoms, the disease is usually in an advanced stage.[1]
- If left untreated, patients with linitis plastica may progress to develop symptoms from decreased peristalsis of the stomach and may include dyspepsia, dysphagia, nausea, vomiting, increased satiety, and regurgitation.[1][2]
Complications
Patients with linitis plastica may progress to develop gastric outlet obstruction from the rigid stomach wall that limits the process of digestion.[3]
Prognosis
- Depending upon the stage of linitis plastica at the time of diagnosis, the prognosis may vary.
- The presence of metastasis is associated with a particularly poor prognosis among patients with linitis plastica because of the rapid peritoneal and lymphatic spread of the disease.
- Linitis plastica is associated with a 5-year survival rate of approximately 10-20% in Japan.[2]
References
- ↑ 1.0 1.1 1.2 Jafferbhoy S, Shiwani H, Rustum Q (2013). "Managing Gastric Linitis Plastica: Keep the scalpel sheathed". Sultan Qaboos Univ Med J. 13 (3): 451–3. PMC 3749031. PMID 23984032.
- ↑ 2.0 2.1 2.2 2.3 Gastric linitis plastica. Orphanet. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?Lng=GB&Expert=36273 Accessed on November 19, 2015.
- ↑ Shiver SA, Blaivas M (2004). "Gastric outlet obstruction secondary to linitis plastica of the stomach as shown on transabdominal sonography". J Ultrasound Med. 23 (7): 989–92. PMID 15292571.