Williams-Campbell syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Cartilage deficiency

Overview

Williams–Campbell syndrome is a disease of the airways where cartilage in the bronchi is defective. This leads to collapse of the airways and bronchiectasis. Williams–Campbell syndrome is deficiency of the bronchial cartilage distally.

Historical Perspective

It was described in 1960 by Howard Williams and Peter Campbell.

Symptoms

• Persistent cough
• Wheeze
• Impaired lung function

Diagnosis

Radiologically, the lungs are overinflated and on bronchoscopy, bronchomalacia is demonstrated.