Sandbox: ATL

prognosis

high lactate dehydrogenase (LDH) high β2‐microglobulin

high serum level of CD25 high serum neuron‐specific enolase

Prognostic Factor	Description
Clinical form	Older age at the time of diagnosis is associated with a worse prognosis.
Age	Males are associated with a worse prognosis when compared to females.
Performance status	Patient's poor performance status is associated with a worse prognosis.
Calcium level	Binet stages B and C or Rai stages 2-4 are associated with a worse prognosis.
Leukocyte count	A rapid lymphocyte doubling time is associated with a worse prognosis.
Lactate dehydrogenase level	Deletion of chromosome 17 short arm and chromosome 11 long arm are associated with a worse prognosis.
β2-microglobulin level	An increased percentage of prolymphocytes is associated with a worse prongnosis.
Histological analysis	Diffuse histology on bone marrow aspiration is associated with a worse prognosis.
Lactate dehydrogenase (LDH) level	Elevated level of LDH is associated with a worse prognosis.
β2-microglobulin level	Elevated level of β2-microglobulin level is associated with a worse prognosis.
Lymphocyte surface markers	Over expression of CD25 is associated with a worse prognosis.
Neuron‐specific enolase	The absence of IgVH gene mutation is associated with a worse prognosis.
Membrane-bound proteins	The expression of zeta-chain-associated protein kinase 70 (ZAP) is associated with a worse prognosis.