Histoplasmosis history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Symptoms

Acute Disease Symptoms

• The incubation period of histoplasmosis is typically 3–17 days for the acute disease.
• The vast majority of infections are asymptomatic or result in a mild influenza-like illness.
• More manifest disease is characterized by:

• Headache
• Nonproductive cough
• Chills
• Weakness
• Pleuritic chest pain
• Fatigue

• Most people spontaneously recover 2–3 weeks after onset of symptoms, although fatigue may persist longer.
• Dissemination, especially to the gastrointestinal tract and central nervous system, can occur in people who are immunocompromised.

Chronic Disease Symptoms

Chronic pulmonary histoplasmosis is characterized by:

• Chronic productive cough
• Excessive fatigue
• Anorexia
• Unintentional weight loss