Sandbox: Langerhans

In 1893, Alfred Hand, Jr. (2), a resident physician at Children's Hospital in Philadelphia, described a child with exophthalmos, diabetes insipidus, skull lesions, and a cutaneous eruption “something like scabies,” which he ascribed to tuberculosis. It was not until 1915 that Artur Schüller (3), working at the Allgemeines Krankenhaus in Vienna, reported another child and an adolescent with skull lesions and exophthalmos. However, the earliest suggestion that this collection of signs might bestereotypic was made by Henry A. Christian, the first physician-in-chief at Peter Bent Brigham Hospital in

Resistance began to fade when Tarnowski & Hashimoto (24) first provided ultrastructural evidence for the phagocytic nature of pathologic LCs.