Sandbox: Langerhans

• Langerhans cell histiocytosis may be classified according to the extent of organs involvement into 4 groups: pulmonary Langerhans cell histiocytosis, unifocal Langerhans cell histiocytosis, multifocal unisystem Langerhans cell histiocytosis, and multifocal multisystem Langerhans cell histiocytosis.
• The table below lists the features of each specific Langerhans cell histiocytosis subtype:

Subtype	Organ Involvement	Age	Risk Factors	Prognosis
Clinical subtype	Acute and lymphomatous subtypes have a poor prognosis, where as chronic and smouldering subtypes have a good prognosis.
Age	Males are associated with a worse prognosis when compared to females.
Performance status	Patient's poor performance status is associated with a worse prognosis.
Performance status	Patient's poor performance status is associated with a worse prognosis.