Langerhans cell histiocytosis natural history
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Natural History
- The clinical course of Langerhans cell histiocytosis may range from a disease that spontaneously regress to a rapidly progressive disease with multi-system involvement.
Complications
- Common complications of Langerhans cell histiocytosis include:
- Pulmonary fibrosis
- Pulmonary hypertension
- Pathological bone fractures
- Anemia
- Recurrent bleeding
- Recurrent infections
- Central diabetes insipidus
Prognosis
- Depending on the extent of the tumor at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as excellent.