Epithelioid sarcoma medical therapy
|
Epithelioid sarcoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Epithelioid sarcoma medical therapy On the Web |
|
American Roentgen Ray Society Images of Epithelioid sarcoma medical therapy |
|
Risk calculators and risk factors for Epithelioid sarcoma medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Medical Therapy
Chemotherapy
- Doxorubicin is the drug of choice.
- The gold standard for chemotherapy is a combination of doxorubicin and ifosfamide. However, recent studies have suggested that the addition of ifosfamide to doxorubicin does not necessarily lead to an increase in overall survival.[1] Etoposide, vincristine, dactinomycin, and cyclophosphamide have also traditionally been given.[2] Newer chemotherapies, such as gemcitabine and pazopanib, are currently being tested in clinical trials.
Radiation Therapy
- Radiation Therapy was used for limb salvage therapy.
Complications of Radiation Therapy
- Scarring
- Stiffness
- Neuropathy
References
- ↑ Judson, Ian; Verweij, Jaap; Gelderblom, Hans; Hartmann, Jörg T; Schöffski, Patrick; Blay, Jean-Yves; Kerst, J Martijn; Sufliarsky, Josef; Whelan, Jeremy; Hohenberger, Peter; Krarup-Hansen, Anders; Alcindor, Thierry; Marreaud, Sandrine; Litière, Saskia; Hermans, Catherine; Fisher, Cyril; Hogendoorn, Pancras C W; dei Tos, A Paolo; van der Graaf, Winette T A (2014). "Doxorubicin alone versus intensified doxorubicin plus ifosfamide for first-line treatment of advanced or metastatic soft-tissue sarcoma: a randomised controlled phase 3 trial". The Lancet Oncology. 15 (4): 415–23. doi:10.1016/S1470-2045(14)70063-4. PMID 24618336.
- ↑ Invalid
<ref>tag; no text was provided for refs namedNCCN Soft Tissue Sarcoma