Lymphangioma pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]
Overview
Pathogenesis
- Lymphangioma arises from lymphatic vessels, which are a vital part of the circulatory and immune system, where they are normally involved in re-circulation of excess body fluid back into the blood stream.
- Lymphangioma is a common benign tumor that often grows proportionally to the patients body growth rate.
- The exact pathogenesis of lymphangioma is not fully understood. It is thought that lymphangioma is the result of is caused by either sequestration of lymph tissue, abnormal budding of lymph vessels, lack of fusion with the venous system, or obstruction of lymph vessels.
- The progression to lymphangioma usually involves the following growth factors:
- VEGF-C
- VEGFR-3
- Prox-1
- bFGF
- PEDF
- Thrombospondin
- Reelin
- cMAF
- Integrin-α1, -α9