Primary cutaneous follicle centre lymphoma pathophysiology

Primary cutaneous follicle centre lymphoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Genetics

Genes involved in the pathogenesis of primary cutaneous follicle centre lymphoma include:

• Amplification of C-REL gene
• BCL2 rearrangements

Gross Pathology

Multinodular mass on the scalp (A) and spectacular response after the second chemotherapy course (B).

Microscopic Pathology

Histopatological fingings. Biopsy of the mass of the scalp showing a dense and diffuse dermal infiltrate with nodular growth pattern (A) consisted of large atypical lymphocytes (H&E) (B), which are positive for CD20 (C) and Bcl6 (D) and negative for Bcl2 (E) on immunohistochemical staining. Bone marrow biopsy showing a hypercellular bone marrow with proliferation of megakaryocytes with hyperlobulated nuclei, sometimes in loose clusters (H&E) (F), positive for CD61 on immunohistochemical staining (G).

References

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