Primary cutaneous follicle centre lymphoma medical therapy
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Differentiating Primary cutaneous follicle centre lymphoma from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overvew
The predominant therapy for primary cutaneous follicle centre lymphoma is radiotherapy. Adjunctive chemotherapy may be required.
Medical Therapy
- Surgical removal and/or radiotherapy is given for localized disease.[1]:314[2]
- Radiation using multiple radiation fields is given if the disease has wider extent with grouped lesions.[1]:314[3][4][2]
- For the less common situation of more extensive disease (still confined to skin), rituximab without chemotherapy is used.[1]:314[3][4][2]Intralesional interferon alpha (IFN-α)[5] and intralesional rituximab have been used.[1]:314[5]
- Approximately one-third of PCFCL relapse, usually in the skin; treatment is similar to initial management[2] and overall survival remains excellent.[6]