Non small cell lung cancer epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]
Overview
Non-small cell lung cancer is the most common cancer worldwide and the leading cause of cancer-related mortality in the United States.[1][2][3][4]Non small cell lung cancer accounted for 1.8 million new cases and 1.6 million deaths of lung cancer in 2012. In the United States, the age-adjusted prevalence of non small cell lung cancer is 47.2 per 100,000 indivudals.[4][5] The median-age at diagnosis of non small cell lung cancer is 70 years.[1] Non small cell lung cancer is most frequently diagnosed among people between 65 to 74 years old. Males are more commonly affected with non small cell lung cancer than females. The male to female ratio is approximately 1.8 to 1. The rate of new cases in 2011 showed that males develop lung cancer more often than females (64.8 and 48.6 per 100,000 individuals). There is a racial preponderance to the development of non small cell lung cancer, where African American individuals are at a significantly increased risk compared to Caucasian race.[4]
Epidemiology and Demographics
Prevalence
- The most common type of lung cancer is non small cell lung cancer[3]
- Non small cell lung cancer is the most common cancer worldwide, accounting for 1.8 million new cases and 1.6 million deaths in 2012
- About 85%–90% of all lung cancers are non small cell lung cancer[6]
- In the United States, the age-adjusted prevalence of non small cell lung cancer is 47.2 per 100,000 indivudals[4]
- Adenocarcinoma of the lung is the most common non small cell lung cancer subtype in the United States
Incidence
- The age-adjusted incidence of non small cell lung cancer in 2012 was estimated to be 58.7 per 100,000 indivudals in the United States[4]
- The incidence rate of lung adenocarcinoma is 22.1 per 100,000 individuals a year
- The incidence rate of lung squamous-cell carcinoma is 14.4 per 100,000 individuals a year
Age
- The incidence of non small cell lung cancer increases with age; the median age at diagnosis is 70 years[1]
- Non small cell lung cancer is most frequently diagnosed among people among 65 to 74 years old
- Shown below is an image that demonstrates the age-adjusted incidence of non small cell lung cancer in the United States. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute[1]
Gender
- Males are more commonly affected with non small cell lung cancer than females. The male to female ratio is approximately 1.8 to 1.[1]
- The rate of new cases in 2011 showed that males develop lung cancer more often than females (64.8 and 48.6 per 100,000 individuals)
Race
- There is a racial preponderance to the development of non small cell lung cancer, where African American individuals are at a significantly increased risk compared to Caucasian race[2]
- There is a higher prevalence of lung adenocarcinoma among Asian female patients with EGFR mutation (51.4%)
- Shown below is an image that demonstrates the mortality rate of non small cell lung cancer among different ethnic groups in the United States. These graphs are adapted from SEER: The Surveillance, Epidemiology, and End Results Program of the National Cancer Institute[1]
References
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 Subramanian J, Morgensztern D, Goodgame B, Baggstrom MQ, Gao F, Piccirillo J, Govindan R (2010). "Distinctive characteristics of non-small cell lung cancer (NSCLC) in the young: a surveillance, epidemiology, and end results (SEER) analysis". J Thorac Oncol. 5 (1): 23–8. doi:10.1097/JTO.0b013e3181c41e8d. PMID 19934774.
- ↑ 2.0 2.1 Tumors of the lung: epidemiology. WHO/IARC. 2006 https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb10/bb10-chap1.pdf Accessed on February 21, 2016
- ↑ 3.0 3.1 Molina JR, Yang P, Cassivi SD, Schild SE, Adjei AA (2008). "Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship". Mayo Clin. Proc. 83 (5): 584–94. doi:10.4065/83.5.584. PMC 2718421. PMID 18452692.
- ↑ 4.0 4.1 4.2 4.3 4.4 Howlader N, Noone AM, Krapcho M, Garshell J, Miller D, Altekruse SF, Kosary CL, Yu M, Ruhl J, Tatalovich Z,Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2011, National Cancer Institute. Bethesda, MD, http://seer.cancer.gov/statfacts/html/lungb.html, based on November 2013 SEER data submission, posted to the SEER web site. February 2016.
- ↑ Alberg AJ, Brock MV, Samet JM (2005). "Epidemiology of lung cancer: looking to the future". J. Clin. Oncol. 23 (14): 3175–85. doi:10.1200/JCO.2005.10.462. PMID 15886304.
- ↑ Non small cell lung cancer. Canadian cancer society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/lung/lung-cancer/non-small-cell-lung-cancer/?region=ab