Donovanosis pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2]; Nate Michalak, B.A.
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Overview
Pathophysiology
Transmission
- Klebsiella granulomatis may be transmitted through sexual contact.
- Although donovanosisis is typically considered a sexually transmitted disease, studies indicate it may also develop through fecal contamination or dermal contact.
- K. granulomatis may also autoinoculate, resulting in multiple lesions that appear to be mirror images of each other.[1]
Pathogenesis
Virulence Factors
Adhesion
Associated Conditions
Microscopic Pathology
- Donovan bodies (K. granulomatis) are seen within phagosomes or in the cytoplasm of monocytes or histocytes.
- Morphology of Donovan bodies:
- Pleomorphic ranging from coccus to bacillus
- 1-2 X 0.5-0.7 μm
- May or may not be capsulated
- Non-motile
- Epidermis of lesion borders show a degree of hyperplasia.
- A dense infiltrate of plasma cells is seen in the dermis.[2]