Myelofibrosis laboratory tests
|
Myelofibrosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Myelofibrosis laboratory tests On the Web |
|
American Roentgen Ray Society Images of Myelofibrosis laboratory tests |
|
Risk calculators and risk factors for Myelofibrosis laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1][2]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
Complete Metabolic Panel
- Raised levels of lactate dehydrogenase
JAK2 Mutation Analysis Testing
- JAK2 mutation on Val 617 Phe locus in 50%
- Reverse transcriptase polymerase chain reaction (RT-PCR) may be performed to observe the JAK2 mutation.
Leukocyte Alkaline Phosphatase Test (LAP Test)
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016