Myelofibrosis laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Laboratory findings consistent with the diagnosis of myelofibrosis include decreased red blood cells, normochromic normocytic anemia, tear-drop shaped RBCs, thrombocytopenia, and raised levels of lactate dehydrogenase.[1][2]
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1][2]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
Complete Metabolic Panel
- Raised levels of lactate dehydrogenase
Leukocyte Alkaline Phosphatase Test (LAP Test)
References
- ↑ 1.0 1.1 Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ 2.0 2.1 Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016