Adult treatment panel guidelines (ATP III) for hypercholestrolemia

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Overview
Classification Familial hyperchylomicronemia Familial hypercholesterolemia Familial combined hyperlipidemia Dysbetalipoproteinemia Primary hypertriglyceridemia Mixed hyperlipoproteinemia
Differential Diagnosis
Screening
ACC/AHA Guideline Recommendations
Summary
Treatment
Major recommendations for statin therapy
Therapeutic response to statin therapy
Blood cholesterol LDL and non-HDL treatment goals
Treatment in heart failure and hemodialysis
Primary prevention
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Intensity of statin therapy in primary and secondary prevention
Safety Recommendations
Guideline on Lifestyle Management

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]

Overview

The Adult Treatment Panel (ATP III) has adopted a classification for serum triglyceride level that helps in making treatment decisions. Elevated triglycerides are an independent risk factor for coronary heart diseases. It is commonly observed in persons with the metabolic syndrome, obesity, physical inactivity, smoking, excess alcohol intake, high-carbohydrate diets , diabetes type 2, chronic renal failure, nephrotic syndrome, certain drugs like corticosteroids, estrogens, retinoids and genetic disorders (familial combined hyperlipidemia, familial hypertriglyceridemia, and familial dysbetalipoproteinemia).

Risk category	LDL goal, mg/dL	Non-HDL goal, mg/dL
CHD and CHD risk equivalent (10 year risk for CHD is >20%)	< 100	< 130
Multiple (2+) risk factor (10 year risk for CHD is <20%)	< 130	< 160
0-1 risk factors	< 160	< 190

ATP III LDL cholesterol and Non-HDL cholesterol goals ^[1]

ATP III classification for triglyceride levels ^[1]