St. Louis encephalitis pathophysiology
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St. Louis encephalitis Microchapters |
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Diagnosis |
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Treatment |
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St. Louis encephalitis pathophysiology On the Web |
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American Roentgen Ray Society Images of St. Louis encephalitis pathophysiology |
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Risk calculators and risk factors for St. Louis encephalitis pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]; Contributor(s): Vishnu Vardhan Serla M.B.B.S. [3]
Overview
St. Louis encephalitis virus is usually transmitted via mosquitos to the human host. St. Louis encephalitis virus contains positive-sense viral RNA; this RNA has its genome directly utilized as if it were mRNA, producing a single protein which is modified by host and viral proteins to form the various proteins needed for replication. Transmission to humans requires mosquito species capable of creating a "bridge" between infected animals and uninfected humans. The incubation period is 5-15 days.[1] Humans are dead-end hosts for the virus, meaning there is an insufficient amount of Japanese encephalitis virus in the blood stream to infect a mosquito; there is also no evidence of person to person spread.[2]
Pathophysiology
St. Louis encephalitis virus is usually transmitted via mosquitos to the human host. St. Louis encephalitis virus contains positive-sense viral RNA; this RNA has its genome directly utilized as if it were mRNA, producing a single protein which is modified by host and viral proteins to form the various proteins needed for replication. The following table is a summary of the St. Louis encephalitis virus:[3][4]
| Characteristic | Data |
|---|---|
| Nucleic acid | RNA |
| Sense | ssRNA(+) |
| Virion | Enveloped |
| Capsid | Spherical |
| Symmetry | Yes; T=3-like organization; icosahedral-like |
| Capsid monomers | Unknown |
| Envelope length (diameter) | 50 nm |
| Additional envelope information | Mature virons contain 2 virus-encoded membrane proteins (M and E); immature virons contain a protein precursor |
| Genome shape | Linear |
| Genome length | 10-11 kb |
| Nucleotide cap | Yes |
| Polyadenylated tail | No; a loop structure is formed instead |
| Incubation period | 5-15 days |
St. Louis encephalitis is contracted by the bite of an infected mosquito, primarily Culex pipiens, Culex tarsalis, and Culex nigripalpus. Japanese encephalitis virus circulates between a mosquito vector and birds in the United States and South America.[5] Transmission to humans requires mosquito species capable of creating a "bridge" between infected animals and uninfected humans; this occurs when humans become part of the enzootic cycle. The incubation period is 5-15 days.[1] Humans are dead-end hosts for the virus, meaning there is an insufficient amount of Japanese encephalitis virus in the blood stream to infect a mosquito; there is also no evidence of person to person spread.[2]
St. Louis encephalitis virus is transmitted in the following pattern:[3]
- Attachment of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis, or by apoptotic mimicry.
- Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
- The positive-sense ssRNA virus is translated into a polyprotein, which is cleaved into all structural and non-structural proteins necessary for RNA synthesis (replication and transcription).
- Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
- The dsRNA genome is transcribed/replicated, thereby providing viral mRNAs/new ssRNA(+) genomes.
- Virus assembly occurs at the endoplasmic reticulum. The virion buds via the host endosomal sorting complexes required for transport (ESCRT), and is sent to the Golgi apparatus.
- The prM protein is cleaved in the Golgi, thereby maturing the virion which is fusion competent.
- New virions are released by exocytosis.
On microscopic histopathological analysis, the enveloped, spherical, and icosahedral-like virion shape are characteristic findings of St. Louis encephalitis.
Image:CULEXT1.jpg|left|Image of culex tarsalis Image:Sle_transmission_cycle_450px.jpg|left|Transmission cycle
Gallery
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Culex tarsalis, one of the major vectors of St. Louis encephalitis virus.
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![Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in urban avian populations, and transmitted to dead end hosts including humans and other mammals by Culex spp. mosquitos. From Public Health Image Library (PHIL). [6]](/images/5/56/Flavivirus03.jpeg)
Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in urban avian populations, and transmitted to dead end hosts including humans and other mammals by Culex spp. mosquitos. From Public Health Image Library (PHIL). [6]
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![Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in rural avian populations, and transmitted to dead end hosts including humans and other mammals by the Culex tarsalis mosquito. From Public Health Image Library (PHIL). [6]](/images/9/99/Flavivirus01.jpeg)
Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in rural avian populations, and transmitted to dead end hosts including humans and other mammals by the Culex tarsalis mosquito. From Public Health Image Library (PHIL). [6]
![Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in urban avian populations, and transmitted to dead end hosts including humans and other mammals by Culex spp. mosquitos. From Public Health Image Library (PHIL). [6]](/index.php/File:Flavivirus03.jpeg)
![Diagram illustrates the methods by which the arbovirus, St. Louis encephalitis virus, reproduces and amplifies itself in rural avian populations, and transmitted to dead end hosts including humans and other mammals by the Culex tarsalis mosquito. From Public Health Image Library (PHIL). [6]](/index.php/File:Flavivirus01.jpeg)
References
- ↑ 1.0 1.1 Saint Louis Encephalitis. Centers for Disease Control and Prevention (CDC), National Center for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases. (2010) http://www.cdc.gov/sle/general/qa.html Accessed on May 3, 2016.
- ↑ 2.0 2.1 Saint Louis Encephalitis Transmission. Centers for Disease Control and Prevention (CDC), National Center for Emerging and Zoonotic Infectious Diseases, Division of Vector-Borne Diseases. (2010) http://www.cdc.gov/sle/technical/transmission.html Accessed on May 3, 2016.
- ↑ 3.0 3.1 Flavivirus. SIB Swiss Institute of Bioinformatics. (2015) http://viralzone.expasy.org/viralzone/all_by_species/24.html Accessed on April 12, 2016
- ↑ Japanese encephalitis - Frequently Asked Questions. CDC Centers for Disease Control and Prevention. (2015) http://www.cdc.gov/japaneseencephalitis/qa/index.html Accessed on April 12, 2016
- ↑ The Management of Encephalitis: Clinical Practice Guidelines by the Infectious Diseases Society of America. http://www.idsociety.org/uploadedFiles/IDSA/Guidelines-Patient_Care/PDF_Library/Encephalitis.pdf Accessed on May 3, 2016.
- ↑ 6.0 6.1 "Public Health Image Library (PHIL)".