Sarcoma botryoides
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2]
Synonyms and keywords: Synonym 1; Synonym 2; Synonym 3
Overview
Sarcoma botryoides is a subtype of embryonal rhabdomyosarcoma. The most commonly affected sites is the vagina, and it occurs more frequently among young girls.
Historical Perspective
- Sarcoma botryoides was first discovered by [scientist name], a [nationality + occupation], in [year] during/following [event].
Classification
- Sarcoma botryoides may be classified according to [classification method] into [number] subtypes/groups:
- [group1]
- [group2]
- [group3]
- Other variants of sarcoma botryoides include [disease subtype 1], [disease subtype 2], and [disease subtype 3].
Pathophysiology
- The pathogenesis of sarcoma botryoides is characterized by [feature1], [feature2], and [feature3].
- The [gene name] gene/Mutation in [gene name] has been associated with the development of sarcoma botryoides.
- On gross pathology, characteristic findings of sarcoma botryoides, include:
- On microscopic histopathological analysis, characteristic findings of sarcoma botryoides, include:
- Rhabdomyoblasts that may contain cross-striations
- Tumor cells are crowded in a distinct layer beneath the vaginal epithelium ( cambium layer)
- Spindle-shaped tumor cells that are desmin positive
Causes
- There are no established causes for sarcoma botryoides.
Differentiating Sarcoma Botryoides from Other Diseases
- Sarcoma botryoides must be differentiated from other diseases that cause [clinical feature 1], [clinical feature 2], and [clinical feature 3], such as:
- [Differential dx1]
- [Differential dx2]
- [Differential dx3]
Epidemiology and Demographics
- The prevalence of sarcoma botryoides is approximately [number or range] per 100,000 individuals worldwide.
Age
- Sarcoma botryoides is more commonly observed among patients aged [age range] years old.
- Sarcoma botryoides is more commonly observed among children.
Gender
- Sarcoma botryoides affects females and males equally.
Race
- There is no racial predilection for sarcoma botryoides.
Risk Factors
- Common risk factors in the development of sarcoma botryoides, include:
Natural History, Complications and Prognosis
- The majority of patients with sarcoma botryoides remain asymptomatic.
- Early clinical features include [manifestation 1], [manifestation 2], and [manifestation 3].
- If left untreated, [#%] of patients with sarcoma botryoides may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
- Common complications of sarcoma botryoides include [complication 1], [complication 2], and [complication 3].
- Prognosis is generally [excellent/good/poor], and the [1/5/10year mortality/survival rate] of patients with sarcoma botryoides is approximately [#%].
Diagnosis
Symptoms
- Sarcoma botryoides is usually asymptomatic.
- Symptoms of sarcoma botryoides may include the following:
- [symptom 1]
- [symptom 2]
- [symptom 3]
- [symptom 4]
- [symptom 5]
- [symptom 6]
Physical Examination
- Patients with sarcoma botryoides usually appear [general appearance].
- Physical examination may be remarkable for:
- [finding 1]
- [finding 2]
- [finding 3]
- [finding 4]
- [finding 5]
- [finding 6]
Laboratory Findings
- There are no specific laboratory findings associated with sarcoma botryoides.
Imaging Findings
- [Imaging study 1] is the imaging modality of choice for sarcoma botryoides.
- On [imaging study 1], sarcoma botryoides is characterized by [finding 1], [finding 2], and [finding 3].
- [Imaging study 2] may demonstrate [finding 1], [finding 2], and [finding 3].
Treatment
Medical Therapy
- There is no treatment for sarcoma botryoides; the mainstay of therapy is supportive care.
- The mainstay of therapy for sarcoma botryoides is [medical therapy 1] and [medical therapy 2].
- [Medical therapy 1] acts by [mechanism of action1].
- Response to [medical therapy 1] can be monitored with [test/physical finding/imaging] every [frequency/duration].
Surgery
- Surgery is the mainstay of therapy for sarcoma botryoides.
- [Surgical procedure] in conjunction with [chemotherapy/radiation] is the most common approach to the treatment of sarcoma botryoides.
- [Surgical procedure] can only be performed for patients with [disease stage] sarcoma botryoides.
Prevention
- There are no primary preventive measures available for sarcoma botryoides.
References
[[Category: Oncology]