Hypogammaglobulinemia
| Hypogammaglobulinemia | |
| ICD-10 | D80.0-D80.1 |
|---|---|
| ICD-9 | 279.00 |
| DiseasesDB | 6426 |
| MedlinePlus | 001307 |
| eMedicine | med/1120 ped/54 |
| MeSH | D000361 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Hypogammaglobulinemia is a type of primary immune deficiency disease.[1]
Hypogammaglobulinemia is a characteristic of common variable immunodeficiency.[2] "Hypogammaglobulinemia" is largely synonymous with "agammaglobulinemia". When the latter term is used (as in "X-linked agammaglobulinemia") it implies that gamma globulins are not merely reduced, but completely absent. Modern assays have allowed most agammaglobulinemias to be more precisely defined as hypogammaglobulinemias,[3] but the distinction is not usually clinically relevant.
"Hypogammaglobulinemia" is distinguished from dysgammaglobulinemia, which is a reduction in some types of gamma globulins, but not others.[4]
Historical Perspective
Classification
| Type | OMIM | Gene |
|---|---|---|
| AGM1 | 601495 | IGHM |
| AGM2 | 613500 | IGLL1 |
| AGM3 | 613501 | CD79A |
| AGM4 | 613502 | BLNK |
| AGM5 | 613506 | LRRC8A |
| AGM6 | 612692 | CD79B |
Pathophysiology
Causes
Differentiating Hypogammaglobulinemia from Other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications, and Prognosis
Natural History
Complications
Prognosis
Diagnosis
Diagnostic Criteria
History and Symptoms
Physical Examination
Laboratory Findings
Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Prevention
External links
- Template:DorlandsDict
- Rose, M. E.; Lang, D. M. (2006). "Evaluating and managing hypogammaglobulinemia". Cleveland Clinic journal of medicine. 73 (2): 133–7, 140, 143–4. PMID 16478038.
- Robert Y Li, et al.: "Hypogammaglobulinemia", Medscape. Accessed 2009-07-17.
- Saul Greenberg: "Hypogammaglobulinemia ". Accessed 2009-07-17.
References
Template:Disorders of globin and globulin proteins Template:Cell surface receptor deficiencies