Hypophysitis

Hypophysitis

WikiDoc Resources for Hypophysitis
Articles
Most recent articles on Hypophysitis Most cited articles on Hypophysitis Review articles on Hypophysitis Articles on Hypophysitis in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Hypophysitis Images of Hypophysitis Photos of Hypophysitis Podcasts & MP3s on Hypophysitis Videos on Hypophysitis
Evidence Based Medicine
Cochrane Collaboration on Hypophysitis Bandolier on Hypophysitis TRIP on Hypophysitis
Clinical Trials
Ongoing Trials on Hypophysitis at Clinical Trials.gov Trial results on Hypophysitis Clinical Trials on Hypophysitis at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Hypophysitis NICE Guidance on Hypophysitis NHS PRODIGY Guidance FDA on Hypophysitis CDC on Hypophysitis
Books
Books on Hypophysitis
News
Hypophysitis in the news Be alerted to news on Hypophysitis News trends on Hypophysitis
Commentary
Blogs on Hypophysitis
Definitions
Definitions of Hypophysitis
Patient Resources / Community
Patient resources on Hypophysitis Discussion groups on Hypophysitis Patient Handouts on Hypophysitis Directions to Hospitals Treating Hypophysitis Risk calculators and risk factors for Hypophysitis
Healthcare Provider Resources
Symptoms of Hypophysitis Causes & Risk Factors for Hypophysitis Diagnostic studies for Hypophysitis Treatment of Hypophysitis
Continuing Medical Education (CME)
CME Programs on Hypophysitis
International
Hypophysitis en Espanol Hypophysitis en Francais
Business
Hypophysitis in the Marketplace Patents on Hypophysitis
Experimental / Informatics
List of terms related to Hypophysitis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords:Autoimmune hypophysitis, lymphocytic hypophysitis

Overview

Hypophysitis is the inflammation of the pituitary gland that typically results in some degree of pituitary dysfunction, ranging from under secretion of some pituitary hormones to complete panhypopituitarism requiring lifelong hormone supplementation. While hypophysitis by itself is seldom life-threatening, the sequelae of pituitary inflammation, particularly adrenal insufficiency and severe hypothyroidism, may be fatal if unrecognized and left untreated. There are several recognized causes of hypophysitis, including lymphocytic infiltration, granulomatous infiltration (e.g. in the setting of a systemic granulomatous disease such as sarcoidosis or granulomatosis with polyangiitis), and cell-mediated autoimmune reactivity in the setting of treatment of certain solid tumors with immunomodulatory checkpoint inhibitors (i.e. CTLA-4 inhibitors and PD-1 inhibitors). Although there are several different subtypes of hypophysitis, there are many commonalities in the diagnostic evaluation and treatment of this rare endocrinopathy.

Template:WikiDoc Sources