Glanzmann's thrombasthenia differential diagnosis

Glanzmann's thrombasthenia
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Glanzmann's thrombasthenia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Electrocardiogram
Chest X Ray
Echocardiography and Ultrasound
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Glanzmann's thrombasthenia differential diagnosis On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Glanzmann's thrombasthenia differential diagnosis All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Glanzmann's thrombasthenia differential diagnosis
CDC on Glanzmann's thrombasthenia differential diagnosis
Glanzmann's thrombasthenia differential diagnosis in the news
Blogs on Glanzmann's thrombasthenia differential diagnosis
Directions to Hospitals Treating Type page name here
Risk calculators and risk factors for Glanzmann's thrombasthenia differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Glanzmann thrombasthenia must be differentiated from other diseases that cause severe hemorrhages , mucocutaneous bleeding , petechiae and ecchymosis, such as Platelet Disorders (like : Bernard-Soulier syndrome,platelet storage pool defects,platelet-type von Willebrand disease and gray platelet syndrome), Fibrinogen abnormalities ,(eg Afibrinogenemia), Von Willebrand Disease and wiskott-Aldrich Syndrome.

Differential Diagnosis

Diseases	Laboratory Findings					Physical Examination				History and Symptoms				Treatment
	Bleeding Time (BT)	PT	aPTT	Platelet count	vWF	Petechiae & Purpura	Ecchymosis	Mucocutaneous hemorrhage	Severe bleeding	Epistaxis	Oral bleeding	Menorrhagia & Postpartum hemorrhage	Hemarthrosis
Glanzmann Thrombasthenia	↑	Normal (Nl)	Nl	lower level of Normal	Nl	+	+	+	+	+	+	+	_	Local hemostatic procedures Anti-fibrinolytic drugs rFVIIa, IVIG, plasmapheresis, corticosteroids, rituximab HSCT
Von Willebrand disease (vWD)	Nl	Nl	↑	Nl	↓	+	+	+	+	+	+	+	_	vWF Desmopressin factor VIII concentrates
Platelet disorder		↓

Variable	Glanzmann Thrombasthenia	Von Willebrand disease (vWD)			Platelet disorder
Pathophysiology	Autosomal recessive (AR) GpIIb/IIIa receptor defect ITGA2B and ITGB3 gene	Autosomal dominant (AD) and autosomal recessive, AR (rare)			Variable depending of type
History & Physical examination	Ecchymosis Epistaxis gingival Bleeding Prolonged bleeding with minor injuries Heavy menstrual bleeding postpartum hemorrhage gastrointestinal bleeding Heavy bleeding during and after surgery	Epistaxis Ecchymosis . Heavy menstrual periods , Postpartum hemorrhage Mucocutaneous hemorrhage Bleeding after surgery in adults.			Superficial bleeding
Labratory findings	Bleeding Time (BT) Prolonged Prothrobin time Normal aPTT Normal Platelet count lower level of Normal vWF Normal
Bleeding Time (BT)	Prolonged
Prothrobin time	Normal	Normal			Normal
aPTT	Normal	Prolonged			Normal
Platelet count	lower level of Normal	Normal			Low
vWF	Normal	Decreased			Normal
Treatment	Local hemostatic procedures Anti-fibrinolytic drugs rFVIIa, IVIG, plasmapheresis, systemic corticosteroids, protein A Sepharose immunoadsorption, cyclophosphamide, azathioprine, chemotherapy and rituximab HSCT	vWF Desmopressin factor VIII concentrates			Depends on type