Heparin-induced thrombocytopenia causes
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Heparin-induced thrombocytopenia |
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Differentiating Heparin-induced thrombocytopenia from other Diseases |
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Diagnosis |
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Treatment |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2], Aric C. Hall, M.D., [3]
Overview
Heparin-induced thrombocytopenia is diagnosed when the platelet count falls by > 50% typically after 5-10 days of heparin therapy. The causes of the condition depends on type of heparin (unfractionated heparin > low molecular weight heparin), duration of therapy, females and type of patients (commoner in surgical patients that require large amount of heparin)
Causes
- HIT is always caused by exogenous heparin or heparinoid exposure.
- Duration of heparin treatment: long duration, up to 2 weeks is associated with the greatest risk.[1]
- The type of heparin involved: unfractionated heparinUFH has a greater risk than low molecular weight heparin LMWH.[1]
- The type of patient: surgical patients are at higher risk than medical; cardiac surgical patients have the highest risk of all.[1]
- Gender: Females have a higher risk of HIT than males.
Reference
- ↑ 1.0 1.1 1.2 Lee GM, Arepally GM (2013). "Diagnosis and management of heparin-induced thrombocytopenia". Hematol Oncol Clin North Am. 27 (3): 541–63. doi:10.1016/j.hoc.2013.02.001. PMC 3668315. PMID 23714311.