Chronic pancreatitis causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
The causes of pancreatitis are many but at least 70% of adult cases are associated with chronic alcohol use, and most patients have consumed more than 80 g/day of alcohol over six to twelve years.[1]
- Major Associations with Chronic Pancreatitis [2][3][4]
- Alcohol
- ≥80 g of ethanol consumption a day for at least 5 years.
- Autoimmunity
- Isolated
- Associated with other systemic disorders (Sjogren syndrome, inflammatory bowel disease, or primary biliary cholangitis)
- Obstruction
- Fibrotic stenosis of either the papilla of Vater or the main pancreatic duct
- Anatomic variations
- Pancreas divisum, Paraduodenal Pancreatitis (Cystic dystrophy of the duodenal wall/groove pancreatitis)
- Metabolic
- Hypercalcemia, Hypertryglyceridemia
- Genetic
- CFTR
- CTRC
- SPINK1
- PRSS1 gene mutations
- Idiopathic
- Alcohol
References
- ↑ Nair RJ, Lawler L, Miller MR (2007). "Chronic pancreatitis". Am Fam Physician. 76 (11): 1679–88. PMID 18092710.
- ↑ Mitchell RMS et al. Pancreatitis. Lancet 2003; 361: 1447–55
- ↑ Frulloni et al. Chronic pancreatitis: Report from a multicenter Italian survey (PanCroInfAISP) on 893 patients. Dig Liver Dis. 2009 Apr;41(4):311-7
- ↑ Adsay NV et al. Paraduodenal pancreatitis: a clinico-pathologically distinct entity unifying "cystic dystrophy of heterotopic pancreas", "para-duodenal wall cyst", and "groove pancreatitis". Semin Diagn Pathol. 2004 Nov;21(4):247-54.