Alpha 1-antitrypsin deficiency x ray

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

On chest Xray Alpha1-antitrypsin deficiency (AATD) emphysema presents as:

a hyperlucent appearance because healthy tissue has been destroyed.
Affected regions also are described as oligemic because they lack the normal rich pattern of branching blood vessels.
An unusual characteristic in alpha1-antitrypsin deficiency is found in about two thirds of PiZZ patients; the emphysema has a striking basilar distribution.
In contrast, cigarette smoking is associated with more severe apical disease.