St. Louis encephalitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]; Contributor(s): Vishnu Vardhan Serla M.B.B.S. [3], Irfan Dotani [4]
Overview
The diagnostic method of choice for St. Louis encephalitis is laboratory testing. In St. Louis encephalitis, cerebrospinal fluid examination shows a moderate (typically lymphocytic) pleocytosis. 2/3 of patients with St. Louis encephalitis may have elevated concentration of CSF protein, which usually indicative of neuroinvasive disease. In the absence of a sensitive and non-invasive virus detection method, serologic testing is the primary method for diagnosing St. Louis encephalitis.[1][2]
Laboratory Findings
The diagnostic method of choice for St. Louis encephalitis is laboratory testing. In St. Louis encephalitis, cerebrospinal fluid examination shows a moderate (typically lymphocytic) pleocytosis. 2/3 of patients with St. Louis encephalitis may have elevated concentration of CSF protein, which usually indicative of neuroinvasive disease. In the absence of a sensitive and non-invasive virus detection method, serologic testing is the primary method for diagnosing SLEV infection. A rapid and accurate diagnosis of St. Louis encephalitis can be made by the detection of St. Louis encephalitis-specific IgM antibody in serum or CSF.[1][2]
Other laboratory findings include:
A positive St. Louis encephalitis IgM test result should be confirmed by neutralizing antibody testing of acute- and convalescent-phase serum specimens at the Centers for Disease Control and Prevention.
References
- ↑ 1.0 1.1 St. Louis Encephalitis Virus Antibodies (IgG, IgM). Quest Diagnostics (2016). http://www.questdiagnostics.com/testcenter/BUOrderInfo.action?tc=34982X&labCode=QTE Accessed on August 1, 2016.
- ↑ 2.0 2.1 Saint Louis Encephalitis. Centers for Disease Prevention and Control (2009). https://www.cdc.gov/sle/technical/symptoms.html Accessed on August 1, 2016.