Sick sinus syndrome pathophysiology
|
Sick sinus syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Sick sinus syndrome pathophysiology On the Web |
|
American Roentgen Ray Society Images of Sick sinus syndrome pathophysiology |
|
Risk calculators and risk factors for Sick sinus syndrome pathophysiology |
Sick sinus syndrome revolves around an improperly propagated signal from the sinoatrial node. Some of the causes for this propagation abnormality include degenerative fibrosis of the SA node, abnormalities in ion-channel conduction, and and a remodeling of the node itself. As a disease of the elderly, it is most commonly thought to be secondary to the age-related idiopathic fibrosis of the nodal tissue.[1] Studies on familial and congenital presentations of sick sinus syndrome have revealed genetic contributions to dysfunctional ion channels.[2] Recent research has revealed a higher incidence of SSS in carriers of the MYH6 susceptibiliy gene, which encodes the alpha heavy chain subunit of cardiac myosin, further delineating a possible genetic basis to the disease. [3]