Strep throat overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
Strep throat (or "Streptococcal pharyngitis", or "Streptococcal Sore Throat") is a form of Group A streptococcal infection that affects the pharynx.
Historical perspective
In the 4th century BC, Hippocrates described scarlet fever epidemic cause as S.pyogenes(GAS). In 1874, Billroth described streptococcal infection for the first time. In 1879, Louis Pasteur isolated the bacteria from a pregnant woman’s blood who was septic.n that had contracted Perpueral Fever. In the late 19th century, Rosenbach designated it as S.pyogenes. Blood agar patterns of streptococcal hemolysis was described by the Brown in 1919. Rebecca Lancefield identified distinct serogroups of beta-hemolytic streptococci in the 1930s.[1][2]
Pathophysiology
Group A strep pharyngitis is most commonly spread through direct person-to-person transmission, typically through saliva or nasal secretions from an infected person. Rarely, contaminated food, especially milk and milk products, can result in outbreaks.[3] The incubation period of group A strep pharyngitis is approximately 2 to 5 days.[3] Pathogenesis of GAS throat involves adhesion of bacteria to pharyngeal mucosa with the help of adhesins on the surface of organism. It then invades the mucosal tissue by producing various proteases and cytolysins causing inflammation manifesting as signs and symptoms of pharyngitis.[4] M protein on the surface of group A streptococcal infection plays important role in the pathogenesis of rheumatic fever.[5]
Genetic association
- HLA-DRB1*07 allele may have a role in recurrent streptococcal pharyngitis and rheumatic heart disease.[6]
- HLA-DRB1*11 allele may have a protective role in rheumatic heart disease.[6]
Causes
Differentiating typhoid fever from other disease
Epidemiology and Demographics
Risk factors
Screening
Natural history and complications
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
X ray
Other diagnostic tests
Treatment
References
- ↑ Alouf JE, Horaud T (1997). "Streptococcal research at Pasteur Institute from Louis Pasteur's time to date". Adv Exp Med Biol. 418: 7–14. PMID 9331588.
- ↑ Joseph Ferretti & Werner Kohler (2016). "History of Streptococcal Research". PMID 26866232.
- ↑ 3.0 3.1 http://www.cdc.gov/groupastrep/diseases-hcp/strep-throat.html Accessed on October 18, 2016
- ↑ Cunningham MW (2000). "Pathogenesis of group A streptococcal infections". Clin Microbiol Rev. 13 (3): 470–511. PMC 88944. PMID 10885988.
- ↑ Guilherme L, Faé KC, Oshiro SE, Tanaka AC, Pomerantzeff PM, Kalil J (2007). "T cell response in rheumatic fever: crossreactivity between streptococcal M protein peptides and heart tissue proteins". Curr Protein Pept Sci. 8 (1): 39–44. PMID 17305559.
- ↑ 6.0 6.1 Haydardedeoğlu FE, Tutkak H, Köse K, Düzgün N (2006). "Genetic susceptibility to rheumatic heart disease and streptococcal pharyngitis: association with HLA-DR alleles". Tissue Antigens. 68 (4): 293–6. doi:10.1111/j.1399-0039.2006.00678.x. PMID 17026463.