Churg-Strauss syndrome laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Laboratory findings consistent with the diagnosis of Eosinophilic granulomatosis with polyangiitis include, antineutrophil cytoplasmic antibodies, hypereosinophilia, and elevated immunoglobulin E titers (IgE).

Laboratory Findings

Laboratory findings consistent with the diagnosis of Eosinophilic granulomatosis with polyangiitis include, antineutrophil cytoplasmic antibodies, hypereosinophilia, and elevated immunoglobulin E titers (IgE). Routine laboratory tests that are used to identify Eosinophila granulomatosis with polyangiitis are:

Blood Work-up

• Complete blood count (CBC)
• Uremia
• Serum creatinine
• Blood urea nitrogen (BUN)
• Antineutrophil cytoplasmic antibody test
• Eosinophilia
• Immunoglobulin
• Erythrocyte sedimentation rate (ESR)
• C-reactive protein (CRP)
• Serum troponin

Urinalysis

• Proteinuria
• Microscopic hematuria
• Red blood cell casts

Biopsy

Renal biopsy is the

Diagnostic markers include eosinophil granulocytes and granulomas in affected tissue and Anti-neutrophil cytoplasmic antibodies (ANCA) against neutrophil granulocytes.

The findings on other laboratory studies is nonspecific. Eosinophilia (5K-9K/uL) may be present. Anemia, elevated erythrocyte sedimentation rate (ESR), leukocytosis, elevated immunoglobin E (IgE), hypergammaglobulinemia, and a low-positive rheumatoid factor (RF