Granulomatosis with polyangiitis differential diagnosis
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Granulomatosis with polyangiitis Microchapters |
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Differentiating Granulomatosis with polyangiitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]Cafer Zorkun, M.D., Ph.D. [4]
Overview
Granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis, such as Microscopic polyangiitis and Eosinophilic granulomatosis with polyangiitis.[1]
Differentiating Granulomatosis with polyangiits from other Diseases
Granulomatosis with polyangiitis must be differentiated from other diseases that cause purpura, alveolar hemorrhage, necrotizing extra-capillary glomerulonephritis, such as Microscopic polyangiitis and Eosinophilic granulomatosis with polyangiitis.[1]
| Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis serological findings | |||
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| Eosinophilic granulomatosis with polyangiitis | Granulomatosis with polyangiitis | Microscopic polyangiitis | |
| Cytoplasmic ANCA (cANCA) | 90% positive | ||
| Perinuclear ANCA (pANCA) | 30 to 40% positive | 60 to 80% positive | |
| Myeloperoxidase antigen | † | † | |
| Protienase 3 antigen | † | ||
Differentiating Granulomatosis with polyangiitis from Other Diseases
Granulomatosis with polyangiitis must be differentiated from other disease that cause purpura, alveolar hemorrhage, fever, arthralgia, myalgia, necrotizing extra-capillary glomerulonephritis and include:[1]
- mononeuritis multiplex
- venous thrombosis
- necrotizing vasculitis of small-sized vessels
- ear nose throat involvement
References
- ↑ 1.0 1.1 1.2 Pagnoux C (2016). "Updates in ANCA-associated vasculitis". Eur J Rheumatol. 3 (3): 122–133. doi:10.5152/eurjrheum.2015.0043. PMID 27733943.