Microscopic polyangiitis history and symptoms

Microscopic polyangiitis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Ali Poyan Mehr, M.D. [2]Associate Editor(s)-in-Chief: Krzysztof Wierzbicki M.D. [3]

Overview

Obtaining a complete history is an important aspect in making a clinical diagnosis of Microscopic polyangiitis. As it can help differentiate between the ANCA associated vasculitis and other possible causes that may mimic the disease. There are many similarities that are present between ANCA associated vasculitis and Microscopic polyangiitis. A history and clinical symptoms can help assess the disease.

History and Symptoms

History

Obtaining a complete history is an important aspect in making a clinical diagnosis of Microscopic polyangiitis. As it can help differentiate between the ANCA associated vasculitis and other possible causes that may mimic the disease.

Signs and Symptoms

The initial signs that are present in patients with Microscopic polyangiitis are non-specific in nature. The following are signs and symptoms of Microscopic polyangiitis:

Most commonly seen signs

• renal inflammation (glomerulonephritis)
• weight loss

• skin lesions

• nerve damage
• pyrexia

Constitutional Symptoms

• weight loss
• malaise
• fatigue
• pyrexia

Ocular involvement:

• conjunctivitis
• episcleritis
• uveitis

Skin involvement:

• palpable purpura
• vesiculobullous lesions
• splinter hemorrhages

Peripheral Nervous System:

• mononeuritis multiplex
• numbness/ tingling
• muscle wasting

Joint involvement:

• myalgia
• arthralgia
• arthritis

Renal involvement:

• hematuria
• protienuria
• red cell casts

Pulmonary involvement:

• alveolar hemorrhage
• pulmonary infiltrates