Aortic regurgitation risk factors

	Aortic Regurgitation Microchapters
Home
Patient Information
Overview
Historical Pesrpective
Pathophysiology
Causes
Stages
Differentiating Aortic Regurgitation from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Cardiac Stress Test
Electrocardiogram
Chest X Ray
Echocardiography
Cardiac MRI
Treatment
Acute Aortic regurgitation Medical Therapy Surgery
Chronic Aortic regurgitation Medical Therapy Surgery
Precautions and Prophylaxis
Special Scenarios Pregnancy Elderly Young Adults End-stage Renal Disease
Case Studies
Case #1
Aortic regurgitation risk factors On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Aortic regurgitation risk factors All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Aortic regurgitation risk factors
CDC on Aortic regurgitation risk factors
Aortic regurgitation risk factors in the news
Blogs on Aortic regurgitation risk factors
Directions to Hospitals Treating Aortic regurgitation
Risk calculators and risk factors for Aortic regurgitation risk factors

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Varun Kumar, M.B.B.S. [2]; Lakshmi Gopalakrishnan, M.B.B.S. [3]; Mohammed A. Sbeih, M.D. [4]

Overview

In the past, the most common risk factor for aortic valvular disease had been the rheumatic fever, with subsequent fibrosis of the scarred valve then leading to retraction of the aortic valve cusps and prevention of their apposition during diastole. In the modern era, a more common risk factor for acquired aortic regurgitation is degenerative disease of the aorta and aortic valve in which case there is calcification and fibrosis of the cusps. Infective endocarditis remains an important risk factor and cause of aortic regurgitation. Congenital conditions such as congenital bicuspid aortic valve or a ventricular septal defect can also result in aortic regurgitation. Patients with bicuspid aortic valve are at increased risk of developing aortic dissection.^[1]

Risk Factors

Risk Factors for Aortic Root Disease

Risk factors for the development of aortic regurgitation due to aortic root disease include:^[2]^[3]^[4]

Ankylosing spondylitis
Aortic dissection
Arteriosclerosis
Bechterew's Disease
Behcet's syndrome
Cystic medial necrosis of the aorta
Ehlers-Danlos Syndrome
Giant cell arteritis
Hypertension
Idiopathic dilation of the ascending aorta
Marfan syndrome
Osteogenesis imperfecta
Polymyalgia Rheumatica
Pseudoxanthoma Elasticum
Psoriatic arthritis
Reiter's syndrome
Relapsing polychondritis
Senile aortic ectasia and dilation
Spondyloarthropathy
Syphilitic aortitis
Takayasu arteritis
Trauma
Ulcerative colitis
Whipple's disease

Risk Factors for Aortic Valve Disease

Risk factors for the development of aortic regurgitation due to aortic valve disease include:^[3]^[4]^[5]^[6]^[7]

Bicuspid aortic valve
Collagen vascular disease
Senile or degenerative calcific aortic valve disease
Endocarditis
Myxomatous aortic valve
Rheumatic fever
Rheumatoid arthritis
Sinus of Valsalva Aneurysm
Systemic Lupus Erythematosus
Trauma
Marfan Syndrome
Turner's Syndrome
Ventricular Septal Defect
Weight loss medications

Risk Factors for Acute Aortic Regurgitation

Risk Factors for Chronic Aortic Regurgitation

References

↑ Fedak PW, Verma S, David TE, Leask RL, Weisel RD, Butany J (2002). "Clinical and pathophysiological implications of a bicuspid aortic valve". Circulation. 106 (8): 900–4. PMID 12186790. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)
↑ Enriquez-Sarano M, Tajik AJ (2004). "Clinical practice. Aortic regurgitation". N Engl J Med. 351 (15): 1539–46. doi:10.1056/NEJMcp030912. PMID 15470217.
↑ ^3.0 ^3.1 Onorati F, De Santo LS, Carozza A, De Feo M, Renzulli A, Cotrufo M (2004). "Marfan syndrome as a predisposing factor for traumatic aortic insufficiency". The Annals of Thoracic Surgery. 77 (6): 2192–4. doi:10.1016/S0003-4975(03)01409-7. PMID 15172299. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)
↑ ^4.0 ^4.1 Prêtre R, Faidutti B (1993). "Surgical management of aortic valve injury after nonpenetrating trauma". The Annals of Thoracic Surgery. 56 (6): 1426–31. PMID 8267458. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)
↑ Bekeredjian, R.; Grayburn, PA. (2005). "Valvular heart disease: aortic regurgitation". Circulation. 112 (1): 125–34. doi:10.1161/CIRCULATIONAHA.104.488825. PMID 15998697. Unknown parameter |month= ignored (help)
↑ Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (22): e57–185. doi:10.1016/j.jacc.2014.02.536. PMID 24603191.
↑ Ribeiro HB, Orwat S, Hayek SS, Larose É, Babaliaros V, Dahou A; et al. (2016). "Cardiovascular Magnetic Resonance to Evaluate Aortic Regurgitation After Transcatheter Aortic Valve Replacement". J Am Coll Cardiol. 68 (6): 577–85. doi:10.1016/j.jacc.2016.05.059. PMID 27491900.
↑ Isner JM (1991). "Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators". Journal of the American College of Cardiology. 17 (6): 1436–44. PMID 2016464. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

Template:WH Template:WS CME Category::Cardiology

[pmid12186790-1] Fedak PW, Verma S, David TE, Leask RL, Weisel RD, Butany J (2002). "Clinical and pathophysiological implications of a bicuspid aortic valve". Circulation. 106 (8): 900–4. PMID 12186790. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)

[pmid15470217-2] Enriquez-Sarano M, Tajik AJ (2004). "Clinical practice. Aortic regurgitation". N Engl J Med. 351 (15): 1539–46. doi:10.1056/NEJMcp030912. PMID 15470217.

[pmid15172299-3] 3.0 ^3.1 Onorati F, De Santo LS, Carozza A, De Feo M, Renzulli A, Cotrufo M (2004). "Marfan syndrome as a predisposing factor for traumatic aortic insufficiency". The Annals of Thoracic Surgery. 77 (6): 2192–4. doi:10.1016/S0003-4975(03)01409-7. PMID 15172299. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)

[pmid8267458-4] 4.0 ^4.1 Prêtre R, Faidutti B (1993). "Surgical management of aortic valve injury after nonpenetrating trauma". The Annals of Thoracic Surgery. 56 (6): 1426–31. PMID 8267458. Retrieved 2011-03-28. Unknown parameter |month= ignored (help)

[Bekeredjian-2005-5] Bekeredjian, R.; Grayburn, PA. (2005). "Valvular heart disease: aortic regurgitation". Circulation. 112 (1): 125–34. doi:10.1161/CIRCULATIONAHA.104.488825. PMID 15998697. Unknown parameter |month= ignored (help)

[pmid24603191-6] Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA; et al. (2014). "2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (22): e57–185. doi:10.1016/j.jacc.2014.02.536. PMID 24603191.

[pmid27491900-7] Ribeiro HB, Orwat S, Hayek SS, Larose É, Babaliaros V, Dahou A; et al. (2016). "Cardiovascular Magnetic Resonance to Evaluate Aortic Regurgitation After Transcatheter Aortic Valve Replacement". J Am Coll Cardiol. 68 (6): 577–85. doi:10.1016/j.jacc.2016.05.059. PMID 27491900.

[pmid2016464-8] Isner JM (1991). "Acute catastrophic complications of balloon aortic valvuloplasty. The Mansfield Scientific Aortic Valvuloplasty Registry Investigators". Journal of the American College of Cardiology. 17 (6): 1436–44. PMID 2016464. Unknown parameter |month= ignored (help); |access-date= requires |url= (help)

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]