Sandbox:splenic abscess

Overview

Splenic abscess is an uncommon and lifethreatening condition.

Classification

• Unilocular abscess
• Bilocular abscess

• Solitary abscess
• Multiple abscesses: More common in HIV patients.

Pathophysiology

Splenic abscess can result from various sources such as

• Splenic trauma or splenic laceration
• Hematogenous spread of bacteria
• Contiguous spread of bacteria

Casuses

Spleenic abscess is caused mostly by monomicrobial but some times it can be caused by polymicrobial agents. Bacteria is more common than other microbial agents such as fungi, protozoa which can cause splenic abscess in immunocompromised patients. Common causes includes:

• Esherichia coli
• Staphylococcus aureus
• Klebsiella pneumonia

Other causes include:

• Streptococcus pyogenes
• Streptococcus pneumonia
• Klebsiella pneumonia
• Bacteroides fragilis
• Pseudomonas aeruginosa
• Staphylococcus aureus
• Proteus mirabilis
• Bacillus cereus

Monomicrobial Most common causes

Risk Factors

Common risk factors of splenic abscess include:

• Diabetes mellitus
• Immunocompromised conditions such as AIDS
• Pulmonary tuberculosis
• Concomitant parenchymal liver disease such as cirrhosis
• Malignancies
• Trauma

Differentiating splenic abscess from other diseases

Splenic abscess should be differented from other causes of left upper quadrent pain causes:

• Splenic cysts
• Splenic hematomas

Epidemiology and Demographics

Incidence

Indceidence of spelenic abscess varies between 0.1% to 0.7%.

Prevalence

Prevalence of splenic abscess is increasing gradually due to increased risk factors and increased imaging modalities that can diagnose more accurately.

Case Fatality Rate

Splenic abscesses are associate with increased morbidity and mortality.

Natural History, Complications and Prognosis

Complications

Common complicaiton include:

• Bacterial sepsis or septicemia
• Respiratory complications such as post operative pneumonia

Other complications include:

• Wound infection
• Paralytic ileus
• Deep vein thrombosis
• Meningitis

Association

Splenic abscess is commonly associate with:

• Paranchymal liver disease
• Pancreatitis
• Pleural effusion
• Renal cysts
• Ovarian cysts
• Abdominal lymphadenopathy

Diagnosis

Splenic abscess commonly present with a triad of symptoms include fever, nausea, vomiting and abdominal pain along with palpable spleen on examination. Early diagnosis with imaging studies and prompt drainage is required to reduce morbidity and mortality.

History and Symptoms

Common symptoms of splenic abscess include:

• Fever
• Abdominal pain
• Nausea and vomiting

Physical Examination Findings

Abdominal Examination

• Tender splenomegaly
• Palpable spleen

Blood Tests

Blood tests such leukocytosis are increased but not significant in the diagnosis of splenic abscess because these tests may not be appropriate in immunocompromised patients.

• CBC with differential
• Erythrocyte sedimentation ratio (ESR)
• Blood culture

Imaging

As the clinical features of splenic absecess are non specific and vague such as abdominal pain, fever and vomiting, that makes diagnosis is challenging and relied on imaging modalities. Imaging studies such as ultrasound, computerized tomography made the diagnosis early and more accurate that reduces morbidity and mortality.

Computerised Tomography

Computerised tomography is both diagnostic and therapeutic test of choice for splenic abscess. Advantages

• Can differentiate unolocular and multilocular abscesses
• Can identify the contents of abscess
• Can differentiate splenic abscess from splenic cysts and splenic hematomas
• More precise and accurate than ultrasonography, in identifying the location of abscess in relation to other internal organs during per-cutaneous drainage.

Treatment

Percutaneous Drainage

Percutaneous drainage is the primary mode of tretament for splenic abscess, even though splenectomy is the definitive treatment because of increased risk of infections in splenectomised patient. It is genereally done under the guidance of imaging studies such as ultrasound or computerised tomography.

• First line of treatment for splenic abscess
• Safe and effective than surgery in both unilocular and bilocular abscesses, especially in peripherally located abscesses.
• Preferred in critically ill patient and patients unfit for general anesthesia

Advantages

• Preserves spleen
• No abdominal spillage of abscess contents
• Less expensive, high acceptance rate and less operative risk

Complications

• Splenic haemorrhage
• Injury to other abdominal organs
• Septicemia
• Empyema
• Pneumothorax
• Fistula formation
• Deep vein thrombosis

Contraindications

• Multiple or septated abscesses
• Anatomically inaccessible for drainage
• Coagulopathies
• Ascites

Splenectomy

Splenectomy is the most effective and definitive treatment of choice for splenic abscess.
Advantages

• Definitive treatment for splenic abscess
• Treatment of choice if more than 2 abscesses are present
• Patients with failed percutaneous drainage
• Patient with recurrent abscesses

Disadvantages

• Splenecetomisesd patients are more prone to infections especially catalase positive bacteria such as staphylococcus aureus.
• Mortality rate varies between 0-20%
• Longer duration of hospital stay than percutaneous drainage procedure

Complications such as

• Lung infection
• Wound infection
• Septicemia
• Paralytic ileus
• Deep vein thrombosis