Fungal meningitis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rim Halaby; Prince Tano Djan, BSc, MBChB [2]
Overview
While cryptococccus and candida infections occur worldwide, other fungal infections tend to cluster in specific geographical regions.[1][2] The most common cause of fungal meningitis is Cryptococcus neoformans.[3][4][2]
Epidemiology
Incidence and prevalence
There is an increasing trend of fungal meningitis. This has been attributed to the following: [2][5]
- Enlarging population of high-risk immunosuppressed patients
- More successful pharmacological immunosuppression and chemotherapies
- Increase in numbers of patients living with human immunodeficiency virus (HIV) infection and the acquired immunodeficiency syndrome (AIDS)
- Migration of susceptible persons into hyperendemic areas
- Aging of the population
Cryptococcus Meningitis
- It is the most common cause of fungal meningitis.[6][4][2]
- Cryptococcus meningitis occurs worldwide but it is highly prevalent in southeast Asia and southern and east Africa where the prevalence of HIV is high.[7]
- It is a common opportunistic infection in patients with HIV and it is considered as an AIDS defining lesion. [8]
Coccidioidomycosis is only found in the Western Hemisphere, especially in the southwestern United States and northwestern Mexico. The annual incidence of disease in areas of endemicity, although not known exactly, appeared to be relatively stable through the middle decades of the 20th century. For reasons only partially explained by population growth and migration and by the existence of a greater number of immunocompromised hosts,
Age
Gender
Race
- Non-Caucasian race have a higher prediclection to developing fungal meningitis especially coccidioidal meningitis[9]
Developed Vs developing countries
Geographic Distribution of Endemic Fungi in The United States
- Blastomyces dermatiditis: Midwest and southeast of USA
- Coccidiodes immitis: Southwest of USA
- Histoplasma Capsulatum: Ohio, central Mississippi River Valley[10]
References
- ↑ Shankar SK, Mahadevan A, Sundaram C, Sarkar C, Chacko G, Lanjewar DN; et al. (2007). "Pathobiology of fungal infections of the central nervous system with special reference to the Indian scenario". Neurol India. 55 (3): 198–215. PMID 17921648.
- ↑ 2.0 2.1 2.2 2.3 Gottfredsson M, Perfect JR (2000). "Fungal meningitis". Semin Neurol. 20 (3): 307–22. doi:10.1055/s-2000-9394. PMID 11051295.
- ↑ Koroshetz WJ. Chapter 382. Chronic and Recurrent Meningitis. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012.
- ↑ 4.0 4.1 Williamson PR, Jarvis JN, Panackal AA, Fisher MC, Molloy SF, Loyse A; et al. (2017). "Cryptococcal meningitis: epidemiology, immunology, diagnosis and therapy". Nat Rev Neurol. 13 (1): 13–24. doi:10.1038/nrneurol.2016.167. PMID 27886201.
- ↑ Fraser DW, Ward JI, Ajello L, Plikaytis BD (1979). "Aspergillosis and other systemic mycoses. The growing problem". JAMA. 242 (15): 1631–5. PMID 480580.
- ↑ Koroshetz WJ. Chapter 382. Chronic and Recurrent Meningitis. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012.
- ↑ Holmes CB, Losina E, Walensky RP, Yazdanpanah Y, Freedberg K (2003) Review of human immunodeficiency virus type 1-related opportunistic infections in Sub-Saharan Africa. Clin Infect Dis, 36, 652–662.
- ↑ Chariyalertsak S, Sirisanthana T, Saengwonloey O, Nelson K (2001) Clinical presentation and risk behaviors of patients with acquired immunodeficiency syndrome in Thailand, 1994–1998: Regional variation and temporal trends. Clin Infect Dis, 32, 955–962.
- ↑ Bouza E, Dreyer JS, Hewitt WL, Meyer RD (1981). "Coccidioidal meningitis. An analysis of thirty-one cases and review of the literature". Medicine (Baltimore). 60 (3): 139–72. PMID 7231152.
- ↑ Koroshetz WJ. Chapter 382. Chronic and Recurrent Meningitis. In: Longo DL, Fauci AS, Kasper DL, Hauser SL, Jameson JL, Loscalzo J, eds. Harrison's Principles of Internal Medicine. 18th ed. New York: McGraw-Hill; 2012.