Heat stroke pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Seyedmahdi Pahlavani, M.D. [2],Usama Talib, BSc, MD [3]
Overview
Pathophysiology
Heat stress means perceived discomfort and physiologic strains during heat exposure. A series of physiologic events happen to adapt heat. These events include thermoregulation (with acclimatization), an acute-phase response, and production of heatshock proteins.
Thermoregulation
The core body temperature is set to 37 °C. Thermoregulatory center is located in hypothalamus, every 1 °C in body temperature activates the peripheral and central receptors to maintain core body temperature at 37 °C.