Diabetes insipidus historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Historical Perspective
- In 1670s Thomas Willis, noted the difference in taste of urine from polyuric subjects compared with healthy individuals and started the differentiation of Diabetes Mellitus from Diabetes Insipidus.
- In 1794, Johann Peter Frank described polyuric patients excreting nonsaccharine urine and introduced the term of Diabetes Insipidus.
- In 1913, a historical milestone was achieved when Farini successfully used posterior pituitary extracts to treat Diabetes Insipidus.
- In the early 1920s the available evidence indicated Diabetes Insipidus as a disorder of the pituitary gland.
- In the early 1928, De Lange first observed that some patients with Diabetes Insipidus did not respond to posterior pituitary extracts.
- Forssman and Waring in 1945 established that the kidney had a critical role for these forms of Diabetes Insipidus resistant to this treatment.
- In 1947 Williams and Henry introduced the term Nephrogenic Diabetes Insipidus for the congenital syndrome characterized by polyuria and renal concentrating defect resistant to vasopressin.
- In 1955, du Vigneaud received the 1955 Nobel Prize in chemistry for the first synthesis of the hormone vasopressin representing a milestone for the treatment of Central Diabetes Insipidus.[1]