Hypogonadism historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Historical perspective

• In 1856, Dr. Maestre de San Juan was the first one to report a case combining small testes (hypogonadism) and loss of smelling sense in a patient.
• In 1944, Dr. Kallmann was the first to identify it as a syndrome which was named based on his name after then. He held a study showing the correlation between anosmia and hypogonadism in different families.
• In the 1950s, Dr. de Morsier reported various cases of patients with hypogonadism and with abscent olfactory bulbs as well. After which, hypogonadism has been described as gonadotropin hormones deficiency.