Zollinger-Ellison syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]

Causes

The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]

Causes of Hypergastrinemia
Appropriate hypergastrinemia
Atrophic gastritis with or without pernicious anemia
Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist)
Chronic renal failure
H pylori pangastritis
Vagotomy
Inappropriate hypergastrinemia
ZES (sporadic or associated with MEN-1)
Antral-predominant H pylori infection
Retained-antrum syndrome
Gastric-outlet obstruction
Small-bowel resection
Spurious hypergastrinemia
Nonfasting patient
Inaccurate assay

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