Zollinger-Ellison syndrome causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]
Overview
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
Causes
The cause of Zollinger-Ellison syndrome has not been identified. However, 25 to 30 percent of gastrinomas, which can cause Zollinger-Ellison syndrome, are caused by multiple endocrine neoplasia type 1 (MEN1).[1]
| Causes of Hypergastrinemia [2] |
| Appropriate hypergastrinemia |
| Atrophic gastritis with or without pernicious anemia |
| Antisecretory therapy (PPIs or high-dose histamine H2-receptor antagonist) |
| Chronic renal failure |
| H pylori pangastritis |
| Vagotomy |
| Inappropriate hypergastrinemia |
| ZES (sporadic or associated with MEN-1) |
| Antral-predominant H pylori infection |
| Retained-antrum syndrome |
| Gastric-outlet obstruction |
| Small-bowel resection |
| Spurious hypergastrinemia |
| Nonfasting patient |
| Inaccurate assay |
References
- ↑ 1.0 1.1 National Institute of Diabetes and Digestive and Kidney Diseases.http://www.niddk.nih.gov/health-information/health-topics/digestive-diseases/zollinger-ellison-syndrome/Pages/facts.aspx#causes
- ↑ Metz DC (2012). "Diagnosis of the Zollinger–Ellison syndrome". Clin Gastroenterol Hepatol. 10 (2): 126–30. doi:10.1016/j.cgh.2011.07.012. PMID 21806955.